Application

Anti-Periostin Antibody (C-term) is an antibody against Periostin (C-term) for use in western blotting.

Research CategoryCell Structure

Research Sub CategoryAdhesion (CAMs)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Periostin, also known as PN, or Osteoblast-specific factor 2 (OSF-2), and encoded by the gene POSTN/OSF2, is a secreted extracellular matrix protein that appears to be involved in inducing cell attachment and spreading as well as cell adhesion. In bone, Periostin enhances mineralization and assists in the incorporation of BMP1 protein into the fibronectin extracellular matrix of connective tissues. Periostin is preferentially expressed in periosteum and periodontal ligaments but can also be found expressed in developing heart and other tissues. Periostin is also over expressed in many cancers where is contributes to a growth-supportive role for such cancers and also aids in chemoresistance for cancers cells through the activation of the PI3K/Akt/surviving pathway.

Immunogen

Epitope: C-terminus

A 188-amino acid bacterial fusion protein from the C-terminal region of mouse periostin.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.

Quality

Evaluated by Western Blotting in mouse lung tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Periostin in 10 µg of mouse lung tissue lysate.

Specificity

This antibody detects a subset of splice variants of Periostin.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~80-85 kDa observed. Multiple splice variants detected.